Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression.

ABSTRACT: Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. This complex disease still holds severe problems concerning diagnosis due to the high invasiveness nature of colonoscopy and the low accuracy of the alternative diagnostic methods. Additionally, patient heterogeneity even within the same stage is not properly reflected in the current stratification system. This scenario highlights the need for new biomarkers to improve non-invasive screenings and clinical management of patients. MicroRNAs (miRNAs) have emerged as good candidate biomarkers in cancer as they are stable molecules, easily measurable and detected in body fluids thus allowing for non-invasive diagnosis and/or prognosis. In this study, we performed an integrated analysis first using 4 different dat

SUBMITTER: Fonseca A 

PROVIDER: S-EPMC8507258 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature