Nucleotide variants in hepatitis B virus preS region predict the recurrence of hepatocellular carcinoma.

ABSTRACT:

Background

Hepatitis B virus (HBV) variants in the preS region have been associated with hepatocellular carcinoma (HCC). However, the effect of the preS variants on HCC prognosis remains largely unknown. We aimed to identify the preS variants that reliably predict postoperative prognosis in HCC.

Methods

RNA-seq data of 203 HCC patients retrieved from public database were screened for the preS variants related to HCC prognosis. The variants in the sera and tumors were then validated in our prospective cohort enrolling 103 HBV-associated HCC patients.

Results

By analyzing prognosis-related gene sets in the RNA-seq data, 12 HBV preS variants were associated with HCC recurrence. Of those, G40C and C147T in the sera predicted an unfavorable recurrence-free survival in our

SUBMITTER: Chen X 

PROVIDER: S-EPMC8507287 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature