Gram-negative microbiota is related to acute exacerbation in children with asthma.

ABSTRACT:

Background

The upper-airway microbiota may be associated with the pathogenesis of asthma and useful for predicting acute exacerbation. However, the relationship between the lower-airway microbiota and acute exacerbation in children with asthma is not well understood. We evaluated the characteristics of the airway microbiome using induced sputum from children with asthma exacerbation and compared the microbiota-related differences of inflammatory cytokines with those in children with asthma.

Methods

We analysed the microbiome using induced sputum during acute exacerbation of asthma in children. We identified microbial candidates that were prominent in children with asthma exacerbation and compared them with those in children with stable asthma using various analytical methods

SUBMITTER: Kim YH 

PROVIDER: S-EPMC8507365 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature