Relationship Between Inflammation and Metabolism in Patients With Newly Presenting Rheumatoid Arthritis.

ABSTRACT:

Background

Systemic inflammation in rheumatoid arthritis (RA) is associated with metabolic changes. We used nuclear magnetic resonance (NMR) spectroscopy-based metabolomics to assess the relationship between an objective measure of systemic inflammation [C-reactive protein (CRP)] and both the serum and urinary metabolome in patients with newly presenting RA.

Methods

Serum (n=126) and urine (n=83) samples were collected at initial presentation from disease modifying anti-rheumatic drug naïve RA patients for metabolomic profile assessment using 1-dimensional ¹H-NMR spectroscopy. Metabolomics data were analysed using partial least square regression (PLS-R) and orthogonal projections to latent structure discriminant analysis (OPLS-DA) with cross validation.

Results

SUBMITTER: Jutley GS 

PROVIDER: S-EPMC8507469 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature