Gene Expression Profiling as a Potential Tool for Precision Oncology in Non-Small Cell Lung Cancer.

ABSTRACT: Recent technological advances and the application of high-throughput mutation and transcriptome analyses have improved our understanding of cancer diseases, including non-small cell lung cancer. For instance, genomic profiling has allowed the identification of mutational events which can be treated with specific agents. However, detection of DNA alterations does not fully recapitulate the complexity of the disease and it does not allow selection of patients that benefit from chemo- or immunotherapy. In this context, transcriptional profiling has emerged as a promising tool for patient stratification and treatment guidance. For instance, transcriptional profiling has proven to be especially useful in the context of acquired resistance to targeted therapies and patients lacking targetable ge

SUBMITTER: Hijazo-Pechero S 

PROVIDER: S-EPMC8507534 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature