Keeping Myeloma in Check: The Past, Present and Future of Immunotherapy in Multiple Myeloma.

ABSTRACT: Multiple myeloma is an incurable disease of malignant plasma cells and an ideal target for modern immune therapy. The unique plasma cell biology maintained in multiple myeloma, coupled with its hematological nature and unique bone marrow microenvironment, provide an opportunity to design specifically targeted immunotherapies that selectively kill transformed cells with limited on-target off-tumor effects. Broadly defined, immune therapy is the utilization of the immune system and immune agents to treat a disease. In the context of multiple myeloma, immune therapy can be subdivided into four main categories: immune modulatory imide drugs, targeted antibodies, adoptive cell transfer therapies, and vaccines. In recent years, advances in all four of these categories have led to improved therap

SUBMITTER: Ackley J 

PROVIDER: S-EPMC8507631 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature