Molecular Stratification of Childhood Ependymomas as a Basis for Personalized Diagnostics and Treatment.

ABSTRACT: Ependymomas are among the most enigmatic tumors of the central nervous system, posing enormous challenges for pathologists and clinicians. Despite the efforts made, the treatment options are still limited to surgical resection and radiation therapy, while none of conventional chemotherapies is beneficial. While being histologically similar, ependymomas show considerable clinical and molecular diversity. Their histopathological evaluation alone is not sufficient for reliable diagnostics, prognosis, and choice of treatment strategy. The importance of integrated diagnosis for ependymomas is underscored in the recommendations of Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy. These updated recommendations were adopted and implemented by WHO experts. This minirevi

SUBMITTER: Zaytseva M 

PROVIDER: S-EPMC8507860 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature