Reproductive Deficits Induced by Prenatal Antimullerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells.

ABSTRACT: Polycystic ovary syndrome (PCOS) is a common reproductive disorder characterized by elevated androgens and antimüllerian hormone (AMH). These hormones remain elevated throughout pregnancy, and potential effects of hormone exposure on offspring from women with PCOS remain largely unexplored. Expanding on recent reports of prenatal AMH exposure in mice, we have fully characterized the reproductive consequences of prenatal AMH (pAMH) exposure throughout the lifespan of first- and second-generation offspring of both sexes. We also sought to elucidate mechanisms underlying pAMH-induced reproductive effects. There is a known reciprocal relationship between AMH and androgens, and in PCOS and PCOS-like animal models, androgen feedback is dysregulated at the level of the hypothalamus. Kisspeptin ne

SUBMITTER: Ho EV 

PROVIDER: S-EPMC8507963 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature