Neonatal Outcomes after Combined Opioid and Nicotine Exposure in Utero: A Scoping Review.

ABSTRACT: The majority of women who are pregnant with opioid use disorder (OUD) also smoke tobacco but are rarely offered tobacco cessation counseling. While the effects of exposure to opioids and nicotine in utero are well-understood separately, understanding the impact of the combined exposure to these substances on neonatal outcomes is lacking. A scoping review was conducted using PubMed and Scopus databases for studies addressing the combined exposure to opioids and nicotine during pregnancy published between 1 January 1980 and 9 July 2019. A total of 29 papers met the eligibility criteria for inclusion, with nine being identified as clinical trials (three from the MOTHER study) and two as secondary data analysis of clinical trial data. Neonatal outcomes for infants who had a combined exposure t

SUBMITTER: Isaacs KR 

PROVIDER: S-EPMC8508043 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature