CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection.

ABSTRACT: High-risk human papillomavirus (hr-HPV) infection of the cervicovaginal tract is known to be the major cause of cervical cancer. Similar to various other countries, Germany introduced an organized combined screening including cytology and HPV testing in 2020. The participation rate was around 70% in the past. Self-testing for hr-HPV infections could be an option to increase the participation rate. Two dry vaginal self-sampling devices and a device for the self-collection of first-void urine were evaluated in combination with a PCR-based hr-HPV test regarding their clinical performance (sensitivity for high-grade cervical intraepithelial neoplasia, CIN 2+). A cervical smear taken by a clinician during colposcopy was used as reference. This open prospective multicenter trial recruited patien

SUBMITTER: Ertik FC 

PROVIDER: S-EPMC8508434 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature