Promising Epigenetic Biomarkers for the Early Detection of Colorectal Cancer: A Systematic Review.

ABSTRACT: In CRC, screening compliance is decreased due to the experienced discomfort associated with colonoscopy, although this method is the gold standard in terms of sensitivity and specificity. Promoter DNA methylation (hypomethylation or hypermethylation) has been linked to all CRC stages. Study objectives: to systematically review the current knowledge on approved biomarkers, reveal new potential ones, and inspect tactics that can improve performance. This research was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines; the risk of bias was evaluated using the revised Quality Assessment of Diagnostic Accuracy Studies criteria (QUADAS-2). The Web of Science® Core Collection, MEDLINE® and Scopus® databases were searched for original

SUBMITTER: Anghel SA 

PROVIDER: S-EPMC8508438 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature