BOLD Coupling between Lesioned and Healthy Brain Is Associated with Glioma Patients' Recovery.

ABSTRACT: Predicting functional outcomes after surgery and early adjuvant treatment is difficult due to the complex, extended, interlocking brain networks that underpin cognition. The aim of this study was to test glioma functional interactions with the rest of the brain, thereby identifying the risk factors of cognitive recovery or deterioration. Seventeen patients with diffuse non-enhancing glioma (aged 22-56 years) were longitudinally MRI scanned and cognitively assessed before and after surgery and during a 12-month recovery period (55 MRI scans in total after exclusions). We initially found, and then replicated in an independent dataset, that the spatial correlation pattern between regional and global BOLD signals (also known as global signal topography) was associated with tumour occurrence. W

SUBMITTER: Romero-Garcia R 

PROVIDER: S-EPMC8508466 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature