Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling.

ABSTRACT: Neural precursors (NPs) present in the hippocampus can be modulated by several neurogenic stimuli, including environmental enrichment (EE) acting through BDNF-TrkB signaling. We have recently identified NPs in meninges; however, the meningeal niche response to pro-neurogenic stimuli has never been investigated. To this aim, we analyzed the effects of EE exposure on NP distribution in mouse brain meninges. Following neurogenic stimuli, although we did not detect modification of the meningeal cell number and proliferation, we observed an increased number of neural precursors in the meninges. A lineage tracing experiment suggested that EE-induced β3-Tubulin+ immature neuronal cells present in the meninges originated, at least in part, from GLAST+ radial glia cells. To investigate the molecula

SUBMITTER: Zorzin S 

PROVIDER: S-EPMC8508649 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature