In Silico Modeling of the Influence of Environment on Amyloid Folding Using FOD-M Model.

ABSTRACT: The role of the environment in amyloid formation based on the fuzzy oil drop model (FOD) is discussed here. This model assumes that the hydrophobicity distribution within a globular protein is consistent with a 3D Gaussian (3DG) distribution. Such a distribution is interpreted as the idealized effect of the presence of a polar solvent-water. A chain with a sequence of amino acids (which are bipolar molecules) determined by evolution recreates a micelle-like structure with varying accuracy. The membrane, which is a specific environment with opposite characteristics to the polar aquatic environment, directs the hydrophobic residues towards the surface. The modification of the FOD model to the FOD-M form takes into account the specificity of the cell membrane. It consists in "inverting" the 3

SUBMITTER: Roterman I 

PROVIDER: S-EPMC8508659 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature