Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties.

ABSTRACT: Being one of the main proteins in the human body and many animal species, albumin plays a decisive role in the transport of various ions-electrically neutral and charged molecules-and in maintaining the colloidal osmotic pressure of the blood. Albumin is able to bind to almost all known drugs, as well as many nutraceuticals and toxic substances, largely determining their pharmaco- and toxicokinetics. Albumin of humans and respective representatives in cattle and rodents have their own structural features that determine species differences in functional properties. However, albumin is not only passive, but also an active participant of pharmacokinetic and toxicokinetic processes, possessing a number of enzymatic activities. Numerous experiments have shown esterase or pseudoesterase activity

SUBMITTER: Belinskaia DA 

PROVIDER: S-EPMC8508759 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature