Dependence of Graphene Oxide (GO) Toxicity on Oxidation Level, Elemental Composition, and Size.

ABSTRACT: The mass production of graphene oxide (GO) unavoidably elevates the chance of human exposure, as well as the possibility of release into the environment with high stability, raising public concern as to its potential toxicological risks and the implications for humans and ecosystems. Therefore, a thorough assessment of GO toxicity, including its potential reliance on key physicochemical factors, which is lacking in the literature, is of high significance and importance. In this study, GO toxicity, and its dependence on oxidation level, elemental composition, and size, were comprehensively assessed. A newly established quantitative toxicogenomic-based toxicity testing approach, combined with conventional phenotypic bioassays, were employed. The toxicogenomic assay utilized a GFP-fused yeast

SUBMITTER: Jiang T 

PROVIDER: S-EPMC8508828 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature