Ontology highlight
ABSTRACT:
SUBMITTER: Mantwill K
PROVIDER: S-EPMC8508870 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Mantwill Klaus K Klein Florian Gerhard FG Wang Dongbiao D Hindupur Sruthi Vasantamadhava SV Ehrenfeld Maximilian M Holm Per Sonne PS Nawroth Roman R
International journal of molecular sciences 20210929 19
Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the management of various cancers. Different concepts of modification within the adenovirus vector have been identified that define the mode of action against and the interaction with the tumour. Adenoviral vectors allow for genetic manipulations that restrict tumour specificity and also the expression of specific transgenes in order to support the anti-tumour effect. Additionally, replication of the virus and rei ...[more]