Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis.

ABSTRACT: Monocarboxylate transporter 2 (MCT2) is a major high-affinity pyruvate transporter encoded by the SLC16A7 gene, and is associated with glucose metabolism and cancer. Changes in the gut microbiota and host immune system are associated with many diseases, including cancer. Using conditionally expressed MCT2 in mice and the TC1 lung carcinoma model, we examined the effects of MCT2 on lung cancer tumor growth and local invasion, while also evaluating potential effects on fecal microbiome, plasma metabolome, and bulk RNA-sequencing of tumor macrophages. Conditional MCT2 mice were generated in our laboratory using MCT2^loxP mouse intercrossed with mCre-Tg mouse to generate MCT2^loxP/loxP; Cre⁺ mouse (MCT2 KO). Male MCT2 KO mice (8 weeks old) were treated with tamox

SUBMITTER: Khalyfa A 

PROVIDER: S-EPMC8508890 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature