The Autophagy-Related Organelle Autophagoproteasome Is Suppressed within Ischemic Penumbra.

ABSTRACT: The peri-infarct region, which surrounds the irreversible ischemic stroke area is named ischemic penumbra. This term emphasizes the borderline conditions for neurons placed within such a critical region. Area penumbra separates the ischemic core, where frank cell loss occurs, from the surrounding healthy brain tissue. Within such a brain region, nervous matter, and mostly neurons are impaired concerning metabolic conditions. The classic biochemical marker, which reliably marks area penumbra is the over-expression of the heat shock protein 70 (HSP70). However, other proteins related to cell clearing pathways are modified within area penumbra. Among these, autophagy proteins like LC3 increase in a way, which recapitulates Hsp70. In contrast, components, such as P2

SUBMITTER: Biagioni F 

PROVIDER: S-EPMC8508911 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature