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From Emollients to Biologicals: Targeting Atopic Dermatitis.


ABSTRACT: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and significantly impacts patients' lives, particularly in its severe forms. AD clinical presentation varies over the course of the disease, throughout different age groups, and across ethnicities. AD is characterized by a spectrum of clinical phenotypes as well as endotypes. Starting from the current description of AD pathogenesis, this review explores the rationale of approved AD therapies from emollients to biologicals and introduces novel promising drugs.

SUBMITTER: Salvati L 

PROVIDER: S-EPMC8508966 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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From Emollients to Biologicals: Targeting Atopic Dermatitis.

Salvati Lorenzo L   Cosmi Lorenzo L   Annunziato Francesco F  

International journal of molecular sciences 20210926 19


Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and significantly impacts patients' lives, particularly in its severe forms. AD clinical presentation varies over the course of the disease, throughout different age groups, and across ethnicities. AD is characterized by a spectrum of clinical phenotypes as well as endotypes. Starting from the current description of AD pathogenesis, this review explores the rationale of approved AD therapies from emollients to biological  ...[more]

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