Cell-Based Regeneration and Treatment of Liver Diseases.

ABSTRACT: The liver, in combination with a functional biliary system, is responsible for maintaining a great number of vital body functions. However, acute and chronic liver diseases may lead to irreversible liver damage and, ultimately, liver failure. At the moment, the best curative option for patients suffering from end-stage liver disease is liver transplantation. However, the number of donor livers required by far surpasses the supply, leading to a significant organ shortage. Cellular therapies play an increasing role in the restoration of organ function and can be integrated into organ transplantation protocols. Different types and sources of stem cells are considered for this purpose, but highly specific immune cells are also the focus of attention when developing individualized therapies. In

SUBMITTER: Hofmann J 

PROVIDER: S-EPMC8508969 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature