Regional Differences in the Permeability Barrier of the Skin-Implications in Acantholytic Skin Diseases.

ABSTRACT: The chemical milieu, microbiota composition, and immune activity show prominent differences in distinct healthy skin areas. The objective of the current study was to compare the major permeability barrier components (stratum corneum and tight junction (TJ)), investigate the distribution of (corneo)desmosomes and TJs, and measure barrier function in healthy sebaceous gland-rich (SGR), apocrine gland-rich (AGR), and gland-poor (GP) skin regions. Molecules involved in cornified envelope (CE) formation, desquamation, and (corneo)desmosome and TJ organization were investigated at the mRNA and protein levels using qRT-PCR and immunohistochemistry. The distribution of junction structures was visualized using confocal microscopy. Transepidermal water loss (TEWL) functional measurements were also p

SUBMITTER: Kapitany A 

PROVIDER: S-EPMC8509001 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature