SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.

ABSTRACT: The mechanisms of neural crest cell induction and specification are highly conserved among vertebrate model organisms, but how similar these mechanisms are in mammalian neural crest cell formation remains open to question. The zinc finger of the cerebellum 1 (ZIC1) transcription factor is considered a core component of the vertebrate gene regulatory network that specifies neural crest fate at the neural plate border. In mouse embryos, however, Zic1 mutation does not cause neural crest defects. Instead, we and others have shown that murine Zic2 and Zic5 mutate to give a neural crest phenotype. Here, we extend this knowledge by demonstrating that murine Zic3 is also required for, and co-operates with, Zic2 and Zic5 during mammalian neural crest specification. At the murine neural plate borde

SUBMITTER: Bellchambers HM 

PROVIDER: S-EPMC8509024 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature