Behaviour of Titanium Dioxide Particles in Artificial Body Fluids and Human Blood Plasma.

ABSTRACT: The growing application of materials containing TiO2 particles has led to an increased risk of human exposure, while a gap in knowledge about the possible adverse effects of TiO2 still exists. In this work, TiO2 particles of rutile, anatase, and their commercial mixture were exposed to various environments, including simulated gastric fluids and human blood plasma (both representing in vivo conditions), and media used in in vitro experiments. Simulated body fluids of different compositions, ionic strengths, and pH were used, and the impact of the absence or presence of chosen enzymes was investigated. The physicochemical properties and agglomeration of TiO2 in these media were determined. The time dependent agglomeration of TiO2 related to the type of TiO2, and mainly to the type and compo

SUBMITTER: Korabkova E 

PROVIDER: S-EPMC8509028 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature