Acetaminophen-Induced Liver Injury Exposes Murine IL-22 as Sex-Related Gene Product.

ABSTRACT: Gaining detailed knowledge about sex-related immunoregulation remains a crucial prerequisite for the development of adequate disease models and therapeutic strategies enabling personalized medicine. Here, the key parameter of the production of cytokines mediating disease resolution was investigated. Among these cytokines, STAT3-activating interleukin (IL)-22 is principally associated with recovery from tissue injury. By investigating paradigmatic acetaminophen-induced liver injury, we demonstrated that IL-22 expression is enhanced in female mice. Increased female IL-22 was confirmed at a cellular level using murine splenocytes stimulated by lipopolysaccharide or αCD3/CD28 to model innate or adaptive immunoactivation. Interestingly, testosterone or dihydrotestosterone reduced IL-22 producti

SUBMITTER: Stulb H 

PROVIDER: S-EPMC8509061 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature