Molecular Modeling of Signal Peptide Recognition by Eukaryotic Sec Complexes.

ABSTRACT: Here, we review recent molecular modelling and simulation studies of the Sec translocon, the primary component/channel of protein translocation into the endoplasmic reticulum (ER) and bacterial periplasm, respectively. Our focus is placed on the eukaryotic Sec61, but we also mention modelling studies on prokaryotic SecY since both systems operate in related ways. Cryo-EM structures are now available for different conformational states of the Sec61 complex, ranging from the idle or closed state over an inhibited state with the inhibitor mycolactone bound near the lateral gate, up to a translocating state with bound substrate peptide in the translocation pore. For all these states, computational studies have addressed the conformational dynamics of the translocon with respect to the pore rin

SUBMITTER: Bhadra P 

PROVIDER: S-EPMC8509349 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature