Changes in Stress-Mediated Markers in a Human Cardiomyocyte Cell Line under Hyperglycemia.

ABSTRACT: Diabetes is a major risk factor for cardiovascular diseases, especially cardiomyopathy, a condition in which the smooth muscles of the heart become thick and rigid, affecting the functioning of cardiomyocytes, the contractile cells of the heart. Uncontrolled elevated glucose levels over time can result in oxidative stress, which could lead to inflammation and altered epigenetic mechanisms. In the current study, we investigated whether hyperglycemia can modify cardiac function by directly affecting these changes in cardiomyocytes. To evaluate the adverse effect of high glucose, we measured the levels of gap junction protein, connexin 43, which is responsible for modulating cardiac electric activities and Troponin I, a part of the troponin complex in the heart muscles, commonly used as cardi

SUBMITTER: Thakur V 

PROVIDER: S-EPMC8509354 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature