Age at Natural Menopause and Blood Pressure Traits: Mendelian Randomization Study.

ABSTRACT: Observational studies suggest that early onset of menopause is associated with increased risk of hypertension. Whether this association is causal or due to residual confounding and/or reverse causation remains undetermined. We aimed to evaluate the observational and causal association between age at natural menopause (ANM) and blood pressure traits in Caucasian women. A cross-sectional and one-sample Mendelian randomization (MR) study was conducted in 4451 postmenopausal women from the CoLaus and Rotterdam studies. Regression models were built with observational data to study the associations of ANM with systolic and diastolic blood pressure (SBP/DBP) and hypertension. One-sample MR analysis was performed by calculating a genetic risk score of 54 ANM-related variants, previously identified

SUBMITTER: Roa-Diaz ZM 

PROVIDER: S-EPMC8509463 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature