Fucose Ameliorates Tritrichomonas sp.-Associated Illness in Antibiotic-Treated Muc2^-/- Mice.

ABSTRACT: The mucus layer in the intestine plays a critical role in regulation of host-microbe interactions and maintaining homeostasis. Disruptions of the mucus layer due to genetic, environmental, or immune factors may lead to inflammatory bowel diseases (IBD). IBD frequently are accompanied with infections, and therefore are treated with antibiotics. Hence, it is important to evaluate risks of antibiotic treatment in individuals with vulnerable gut barrier and chronic inflammation. Mice with a knockout of the Muc2 gene, encoding the main glycoprotein component of the mucus, demonstrate a close contact of the microbes with the gut epithelium which leads to chronic inflammation resembling IBD. Here we demonstrate that the Muc2^-/- mice harboring a gut protozoan infection

SUBMITTER: Achasova KM 

PROVIDER: S-EPMC8509520 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature