Allele frequency divergence reveals ubiquitous influence of positive selection in Drosophila.

ABSTRACT: Resolving the role of natural selection is a basic objective of evolutionary biology. It is generally difficult to detect the influence of selection because ubiquitous non-selective stochastic change in allele frequencies (genetic drift) degrades evidence of selection. As a result, selection scans typically only identify genomic regions that have undergone episodes of intense selection. Yet it seems likely such episodes are the exception; the norm is more likely to involve subtle, concurrent selective changes at a large number of loci. We develop a new theoretical approach that uncovers a previously undocumented genome-wide signature of selection in the collective divergence of allele frequencies over time. Applying our approach to temporally resolved allele frequency measurements from lab

SUBMITTER: Bertram J 

PROVIDER: S-EPMC8509871 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature