A signature of Neanderthal introgression on molecular mechanisms of environmental responses.

ABSTRACT: Ancient human migrations led to the settlement of population groups in varied environmental contexts worldwide. The extent to which adaptation to local environments has shaped human genetic diversity is a longstanding question in human evolution. Recent studies have suggested that introgression of archaic alleles in the genome of modern humans may have contributed to adaptation to environmental pressures such as pathogen exposure. Functional genomic studies have demonstrated that variation in gene expression across individuals and in response to environmental perturbations is a main mechanism underlying complex trait variation. We considered gene expression response to in vitro treatments as a molecular phenotype to identify genes and regulatory variants that may have played an important r

SUBMITTER: Findley AS 

PROVIDER: S-EPMC8509894 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature