Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.

ABSTRACT: Particulate matter (PM) is considered the most severe environmental pollution problem due to its serious effects on human health associated with an increased risk of cardiovascular morbidity and mortality. In this work, a physicochemical characterization of PM10 from the city of Medellin was developed. The results evince that lead (Pb) is one of the most abundant elements since it is present in all analyzed samples. Therefore, Pb was chosen to perform an in-silico study to assess its effects on atrial arrhythmias generation. For this purpose, we developed a model representing the Pb2+ blocking effect on the L-type calcium channel. This formulation was incorporated in a human atrial cell mathematical model and in 2D and 3D models of human atria. The simulations showed a proarrhythmic effect

SUBMITTER: Palacio LC 

PROVIDER: S-EPMC8509962 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature