Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli.

ABSTRACT: Pyrithione (2-mercaptopyridine-N-oxide) is a metal binding modified pyridine, the antibacterial activity of which was described over 60 years ago. The formulation of zinc-pyrithione is commonly used in the topical treatment of certain dermatological conditions. However, the characterisation of the cellular uptake of pyrithione has not been elucidated, although an unsubstantiated assumption has persisted that pyrithione and/or its metal complexes undergo a passive diffusion through cell membranes. Here, we have profiled specific membrane transporters from an unbiased interrogation of 532 E. coli strains of knockouts of genes encoding membrane proteins from the Keio collection. Two membrane transporters, FepC and MetQ, seemed involved in the uptake of pyrithione and its cognate metal

SUBMITTER: Salcedo-Sora JE 

PROVIDER: S-EPMC8510280 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature