Computational drug repositioning of atorvastatin for ulcerative colitis.

ABSTRACT:

Objective

Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatment and disease maintenance. We hypothesized that a multi-cohort analysis of independent cohorts representing real-world heterogeneity of UC would identify a robust transcriptomic signature to improve identification of FDA-approved drugs that can be repurposed to treat patients with UC.

Materials and methods

We performed a multi-cohort analysis of 272 colon biopsy transcriptome samples across 11 publicly available datasets to identify a robust UC disease gene signature. We compared the gene signature to in vitro transcriptomic profiles induced by 781 FDA-approved drugs to identify potential drug targets. We used a retrospective cohort study desi

SUBMITTER: Bai L 

PROVIDER: S-EPMC8510297 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature