Temperature Influences the Composition and Cytotoxicity of Extracellular Vesicles in Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is a pathogenic bacterium but also a commensal of skin and anterior nares in humans. As S. aureus transits from skins/nares to inside the human body, it experiences changes in temperature. The production and content of S. aureus extracellular vesicles (EVs) have been increasingly studied over the past few years, and EVs are increasingly being recognized as important to the infectious process. Nonetheless, the impact of temperature variation on S. aureus EVs has not been studied in detail, as most reports that investigate EV cargoes and host cell interactions are performed using vesicles produced at 37°C. Here, we report that EVs in S. aureus differ in size and protein/RNA cargo depending on the growth temperature used. We demonstrate that the temperature-dependent reg

SUBMITTER: Briaud P 

PROVIDER: S-EPMC8510519 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature