Tissue and sex-specific programming of DNA methylation by perinatal lead exposure: implications for environmental epigenetics studies.

ABSTRACT: Early developmental environment can influence long-term health through reprogramming of the epigenome. Human environmental epigenetics studies rely on surrogate tissues, such as blood, to assess the effects of environment on disease-relevant but inaccessible target tissues. However, the extent to which environment-induced epigenetic changes are conserved between these tissues is unclear. A better understanding of this conservation is imperative for effective design and interpretation of human environmental epigenetics studies. The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET II) consortium was established by the National Institute of Environmental Health Sciences to address the utility of surrogate tissues as proxies for toxicant-induced ep

SUBMITTER: Svoboda LK 

PROVIDER: S-EPMC8510611 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature