Transcriptomic and epigenomic effects of insoluble particles on J774 macrophages.

ABSTRACT: Here we report epigenomic and transcriptomic changes in a prototypical J774 macrophage after engulfing talc or titanium dioxide particles in presence of estrogen. Macrophages are the first immune cells to engage and clear particles of various nature. A novel paradigm is emerging, that exposure to so-called 'inert' particulates that are considered innocuous is not really free of consequences. We hypothesized that especially the insoluble, non-digestible particles that do not release a known hazardous chemical can be underappreciated agents acting to affect the regulation inside macrophages upon phagocytosis. We performed gene chip microarray profiling and found that talc alone, and especially with oestrogen, has induced a substantially more prominent gene expression change than titanium dio

SUBMITTER: Emi T 

PROVIDER: S-EPMC8510616 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature