Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P-gp.

ABSTRACT: Bulbus fritillariae and Radix aconiti praeparata are an incompatible herbal pair in the traditional Chinese medicine theory "eighteen incompatible medicaments," and they should not be used simultaneously in clinical treatment for safety. This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti praeparata based on their interaction with P-glycoprotein (P-gp). The interaction between Bulbus fritillariae and Radix aconiti praeparata during in vitro decocting as well as in vivo absorption was investigated by determining the dry extract yield and by rat single-pass intestinal perfusion (SPIP) model. Inhibition of different species of Bulbus fritillariae on P-gp function was examined

SUBMITTER: Liu W 

PROVIDER: S-EPMC8510812 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature