A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice.

ABSTRACT: During muscle contraction, myosin motors anchored to thick filaments bind to and slide actin thin filaments. These motors rely on energy derived from ATP, supplied, in part, by diffusion from the sarcoplasm to the interior of the lattice of actin and myosin filaments. The radial spacing of filaments in this lattice may change or remain constant during contraction. If the lattice is isovolumetric, it must expand when the muscle shortens. If, however, the spacing is constant or has a different pattern of axial and radial motion, then the lattice changes volume during contraction, driving fluid motion and assisting in the transport of molecules between the contractile lattice and the surrounding intracellular space. We first create an advective-diffusive-reaction flow model and show that the

SUBMITTER: Cass JA 

PROVIDER: S-EPMC8510861 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature