The selective degradation of sirtuins via macroautophagy in the MPP⁺ model of Parkinson's disease is promoted by conserved oxidation sites.

ABSTRACT: The sirtuin (SIRT) protein family has been of major research interest over the last decades because of their involvement in aging, cancer, and cell death. SIRTs have been implicated in gene and metabolic regulation through their capacity to remove acyl groups from lysine residues in proteins in an NAD⁺-dependent manner, which may alter individual protein properties as well as the histone-DNA interaction. Since SIRTs regulate a wide range of different signaling cascades, a fine-tuned homeostasis of these proteins is imperative to guarantee the function and survival of the cell. So far, however, how exactly this homeostasis is established has remained unknown. Here, we provide evidence that neuronal SIRT degradation in Parkinson's disease (PD) models is executed by autophagy rathe

SUBMITTER: Baeken MW 

PROVIDER: S-EPMC8511006 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature