Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules.

ABSTRACT: The V-shaped arrangement of hair bundles on cochlear hair cells is critical for auditory sensing. However, regulation of hair bundle arrangements has not been fully understood. Recently, defects in hair bundle arrangement were reported in postnatal Dishevelled-associating protein (ccdc88c, alias Daple)-deficient mice. In the present study, we found that adult Daple^-/- mice exhibited hearing disturbances over a broad frequency range through auditory brainstem response testing. Consistently, distorted patterns of hair bundles were detected in almost all regions, more typically in the basal region of the cochlear duct. In adult Daple^-/- mice, apical microtubules were irregularly aggregated, and the number of microtubules attached to plasma membranes was decreased. Simila

SUBMITTER: Ozono Y 

PROVIDER: S-EPMC8511111 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature