Quantitative T₁ and T₂ mapping by magnetic resonance fingerprinting (MRF) of the placenta before and after maternal hyperoxia.

ABSTRACT:

Introduction

MR relaxometry has been used to assess placental exchange function, but methods to date are not sufficiently fast to be robust to placental motion. Magnetic resonance fingerprinting (MRF) permits rapid, voxel-wise, intrinsically co-registered T₁ and T₂ mapping. After characterizing measurement error, we scanned pregnant women during air and oxygen breathing to demonstrate MRF's ability to detect placental oxygenation changes.

Methods

The accuracy of FISP-based, sliding-window reconstructed MRF was tested on phantoms. MRF scans in 9-s breath holds were acquired at 3T in 31 pregnant women during air and oxygen breathing. A mixed effects model was used to test for changes in placenta relaxation times between physiological states, to assess the

SUBMITTER: Stout JN 

PROVIDER: S-EPMC8511125 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature