Seasonality of tuberculosis in intermediate endemicity setting dominated by reactivation diseases in Hong Kong.

ABSTRACT: Summer-spring predominance of tuberculosis (TB) has been widely reported. The relative contributions of exogenous recent infection versus endogenous reactivation to such seasonality remains poorly understood. Monthly TB notifications data between 2005 and 2017 in Hong Kong involving 64,386 cases (41% aged ≥ 65; male-to-female ratio 1.74:1) were examined for the timing, amplitude, and predictability of variation of seasonality. The observed seasonal variabilities were correlated with demographics and clinical presentations, using wavelet analysis coupled with dynamic generalised linear regression models. Overall, TB notifications peaked annually in June and July. No significant annual seasonality was demonstrated for children aged ≤ 14 irrespective of gender. The strongest seasonality was d

SUBMITTER: Lau LHW 

PROVIDER: S-EPMC8511215 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature