Plasma glycated CD59 predicts postpartum glucose intolerance after gestational diabetes.

ABSTRACT:

Aim

To assess whether in women with gestational diabetes mellitus (GDM), postpartum plasma glycated CD59 (pGCD59) levels predict conversion to glucose intolerance diagnosed with an oral glucose tolerance test (OGTT).

Methods

Blood levels of pGCD59 were measured in a case-control study of 105 women with GDM who underwent a 75 g OGTT 3 months postpartum. The 35 postpartum glucose intolerant cases were individually matched for age, BMI, ethnic origin, and parity with 70 women with GDM but normal postpartum OGTT (controls). The GDM cohort (105) was also matched with 105 normal glucose tolerant women during pregnancy. pGCD59 was measured by ELISA in standard peptide units (SPU).

Results

Mean pGCD59 postpartum was significantly higher in cases than in controls (1.5 ± 0.6 SP

SUBMITTER: Benhalima K 

PROVIDER: S-EPMC8511340 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature