Dataset Information

A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients.

ABSTRACT:

Background

The World Health Organization guidelines did not make a recommendation on use of remdesivir based on disease severity. Little is known regarding effectiveness of remdesivir in critically ill coronavirus disease 2019 (COVID-19) patients. This has led to a state of dilemma for doctors leaving them skeptical of whether they should continue to recommend the drug or not.

Materials and methods

A systematic search adhering to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines was conducted from inception until February 20, 2020. Electronic bibliographic databases (PubMed, Cochrane database, Scopus, Embase) were included. Using dichotomous data for select values, the unadjusted odds ratios (ORs) were calculated applying Mantel Haenszel (M-H) using random-effects model. The primary outcome of interest was all-cause mortality in ventilated and non-ventilated patients.

Results

The Remdesivir arm was associated with similar rates of 28-day all-cause mortality (OR: 0.93, 95% confidence interval [CI]: 0.80 - 1.08; P = 0.33). Remdesivir was not found to be favorable for ventilated patients. Non ventilated COVID-19 patients showed a significant lower in-hospital mortality rate as compared with patients requiring mechanical ventilatory support (OR: 6.86, 95% CI: 5.39 - 268.74; P <0.0001).

Conclusion

Non-ventilated patients were associated with significant lower all-cause mortality rates. Prudent use of remdesivir is recommended in critically ill COVID-19 patients.

SUBMITTER: Razzack AA

PROVIDER: S-EPMC8511372 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients.

Razzack Aminah Abdul AA Hassan Syed Adeel SA Pasya Sai Kumar Reddy SKR Erasani Greeshma G Kumar Sham S Rocha-Castellanos Dario Missael DM Lopez-Mendez Alfonso A Razzack Sarah Abdul SA

Infection & chemotherapy 20210830 3

<h4>Background</h4>The World Health Organization guidelines did not make a recommendation on use of remdesivir based on disease severity. Little is known regarding effectiveness of remdesivir in critically ill coronavirus disease 2019 (COVID-19) patients. This has led to a state of dilemma for doctors leaving them skeptical of whether they should continue to recommend the drug or not.<h4>Materials and methods</h4>A systematic search adhering to preferred reporting items for systematic reviews an ...[more]

PMID: 34508325

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Dataset Information

A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients.

Background

Materials and methods

Results

Conclusion

Publications

A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients.

Similar Datasets

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