Expression and clinical significance of NUF2 in kidney renal clear cell carcinoma.

ABSTRACT:

Background

To explore the expression and clinical significance of the cytokinesis-related gene NUF2 in kidney renal clear cell carcinoma (KIRC).

Methods

Gene expression profiles of KIRC patients were extracted from The Cancer Genome Atlas (TCGA) database. The differences in NUF2 mRNA expression between patients and controls, as well as the relationship between the clinical characteristics and overall survival of the patients, were analyzed. The expression of NUF2 protein in 83 cancer tissues and para-cancerous tissues was detected to analyze the relationship with clinical characteristics. Gene Set Enrichment Analysis (GSEA) was used to investigate the possible regulatory pathways of the NUF2 in the development of KIRC.

Results

NUF2 mRNA was

SUBMITTER: Shan L 

PROVIDER: S-EPMC8511540 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature