The prognostic roles of CYP19A1 expression in bladder cancer patients of different genders.

ABSTRACT:

Background

The incidence of bladder cancer (BCa) in male is approximately three to four times higher than in female, but the oncological outcomes in female patients with BCa are significantly worse than in male patients. Although many biomarkers have been identified in recent decades to predict the prognosis of BCa patients, few of them are able to distinguish the prognosis of BCa patients with gender difference. Aromatase encoded by the CYP19A1 gene catalyzes the conversion of androgens to estrogens. In this study, we investigate the prognosis significance of CYP19A1 expression considering the gender difference in BCa patients from four available public databases.

Methods

Four available public databases of BCa, including GSE13507, TCGA-BLCA, E-MTAB-4321, and E-MTAB-1803, we

SUBMITTER: Cai S 

PROVIDER: S-EPMC8511542 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature