STAT3 as a Potential Target for Tumor Suppressive Effects of 15-Deoxy-Δ^12,14-prostaglandin J₂ in Triple Negative Breast Cancer.

ABSTRACT: STAT3 plays a prominent role in proliferation and survival of tumor cells. Thus, STAT3 has been considered to be a prime target for development of anti-cancer therapeutics. The electrophilic cyclopentenone prostaglandin,15-deoxy-Δ^12,14-prostaglandin J₂ (15d-PGJ₂) has been well recognized for its capability to modulate intracellular signaling pathways involved in cancer cell growth and progression. We previously reported that 15d-PGJ₂ had potent cytotoxicity against harvey-ras transformed human mammary epithelial cells through direct interaction with STAT3. In this study, we have attempted to verify the inhibitory effects of 15d-PGJ₂ on STAT3 signaling in human breast tumor cells. The triple negative breast cancer cell lines, MDA

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC8511581 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature