Characterizing Enterotypes in Human Metagenomics: A Viral Perspective.

ABSTRACT: The diversity and high genomic mutation rates of viral species hinder our understanding of viruses and their contributions to human health. Viral enterotypes as a description of the gut virome, its characteristics have not been thoroughly studied. Here we investigated the human gut virome composition using previously published sequencing data of 2,690 metagenomes from seven countries with various phenotypes. We found that the virome was dominated by double-stranded DNA viruses in our data, and young children and adults showed different stages in their fecal enterovirus composition. Beta diversity showed there were significantly less homogeneous in individuals with severe disorders of bile acid secretion, such as cirrhosis. In contrast, there were no significant differences in distances to

SUBMITTER: Song L 

PROVIDER: S-EPMC8511818 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature