EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients.

ABSTRACT: Objective: This study was undertaken to investigate eukaryotic translation initiation factor 3 subunit B (EIF3B) expression and its clinical value for indicating disease progression and prognosis in adult Philadelphia chromosome negative acute lymphoblastic leukemia (Ph^- ALL) patients. Methods: Totally, 76 adult Ph^- ALL patients and 30 healthy donors (HDs) were included. Bone marrow (BM) samples before therapy (baseline), after 4-week therapy of Ph^- ALL patients and the BM samples of HDs were collected. Then, EIF3B expression in BM was detected by reverse transcription quantitative polymerase chain reaction. Results: EIF3B expression was increased in Ph^- ALL patients compared with HDs, which distinguished Ph^- ALL p

SUBMITTER: Zhu F 

PROVIDER: S-EPMC8511920 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature